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The ideal injectable hydrogel for OA treatment to promote cartilage regeneration and joint repair should generally meet the following criteria: (a) Easy to administer under physiological conditions, (b) guaranteed injectable (by chemical or physical cross-linking gelation during injection), (c) excellent biocompatibility and potential biodegradability, (d) able to mimic cartilage ECM characteristics and promote the chondrogenic potential of cells, (e) can easily fill the defect site of the joint and integrate with the surrounding natural cartilage tissue without displacement, and (f) has sustained release properties if related to local drug delivery (Yu and Ding, 2008