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Intestinal bacterial excess is more likely to happen in patients with Hashimotos thyroiditis, and studies suggest that HT is caused by modifications in intestinal flora, increased intestinal permeability and bacterial expansion

Dosage ranges reported in literature: Conservative start: 200 to 250 mcg daily, split into two doses of 100 to 125 mcg administered 12 hours apart Standard protocol: 300 to 400 mcg daily, considered the optimal range for most healing applications based on clinical observations Acute injury protocol: 400 to 500 mcg daily, split into two to three doses throughout the day Weight-based considerations: Under 150 pounds: 200 to 300 mcg daily 150 to 200 pounds: 300 to 400 mcg daily Over 200 pounds: 400 to 500 mcg daily Cycle length typically runs four to eight weeks, with some practitioners suggesting six to twelve weeks followed by a four to eight week break

Furthermore, some individuals find that keeping a diary of their outbreaks can help identify patterns or specific triggers, allowing for more proactive management of their symptoms

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Phase III is funded from a private or non-SBIR government source for commercialization or continued development and testing from an effort made under prior SBIR funding