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These data also raise the possibility of tissue GLP-1 resistance as a key factor underlying the failure to improve lipid tolerance in mouse models characterized by reduced DPP-4 activity, elevated levels of GLP-1, and yet normal or deteriorated lipid tolerance

Clinical trials of GLP-1 medications have shown that while weight loss occurs, it includes both fat mass and some lean mass reduction, though the impact on respiratory muscle function specifically has not been well established

Both studies confirm the phenomenon of hormesis

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Apoptosis 25:73