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The C-terminal domain consists entirely of -helices, in which an electrophile substrate binding site (H-site) with hydrophobic characteristics and broad substrate specificities exists

Similarly, liraglutide treatment significantly reduced LPS-induced upregulation of Il-6 , Cox2 , and Tnf- in RAW 264.7 cells ( p = 0.0286 compared to LPS group) in a dose-dependent manner (Fig