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Still, Wong and colleagues concluded that semaglutide could have a significant impact on reducing health care costs associated with obesity and CVD. The ongoing SELECT trial will document the actual impact of semaglutide treatment on cardiovascular outcomes in high-risk adults and established CVD and without diabetes, they wrote.

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[34] [35] G6PD, in contrast, is inhibited by NADPH and by acyl-CoAs, which are intermediates in fatty acid biosynthesis

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Wegovy and Saxenda maker Novo Nordisk responded by pulling back rebates previously offered to current patients, increasing their costs for prescriptions by more than $50 million