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Several mechanisms have been proposed, including effects on plasma membrane Ca 2 + pumps (Tsokos-Kuhn, 1989), which can lead to Ca 2 + -induced DNA damage (Ray et al ., 1990), mito-chondrial damage (Meyers et al ., 1988) resulting in glutathione depletion and oxidative stress (Jaeschke, 1990) and apoptosis (Ray et al ., 1996)

This incidence was significantly higher compared to patients not on a GLP-1 RA, showing a strong link between GLP-1 RA drugs and potential aspiration risk under anesthesia. said author Sudipta Sen MD, anesthesiologist and associate professor, UTHealth in Houston