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SLC7A5 expression is regulated by ATF4 (ATF4 is a known transcriptional activator of ASNS expression) under low leucine conditions via the GAAC pathway and by c-Myc through direct promoter binding, while HIF-2 enhances SLC7A5-mediated mTORC1 phosphorylation (161)

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Contact your provider or seek emergency care if you experience: Seizures Severe mood changes (including worsening depression or suicidal thoughts) Hallucinations, paranoia, or confusion Rapid or irregular heartbeat Signs of an allergic reaction (such as a rash, swelling, or difficulty breathing) On top of the above, Wellbutrin carries an FDA black box warning about the potential for increased suicidal thoughts and behaviors in children, adolescents, and young adults

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