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In large vessel occlusion (LVO) stroke patients with salvageable penumbra, successful reperfusion by endovascular therapy (EVT) may enable the therapeutic potential of GLP-1RAs to be manifested by: 1) enabling better delivery of the drug and its secondary mediators to vulnerable brain tissues with ischemic injury (even though this is yet to be verified in animal models comparing drug distribution with and without reperfusion under otherwise identical experimental conditions), 2) counteraction of reperfusion injury and neuroinflammation once blood flow is restored, and 3) stabilization of the BBB

For neurological applications, nasal delivery offers potential advantages through anatomical proximity to the central nervous system

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Academic press 105:121126

"GLP-1 users face specific nutritional challenges and finding products tailored to these needs can be challenging," said Tabitha Daley, a Registered Dietitian nutritionist with The Vitamin Shoppe who helped formulate the GLP-1 Support from Whole Health Rx products