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However, this explanation is limited to the indirect pathway via D2 receptors, and the role of the direct pathway remains unclear

25, 38 As aberrations in the TP53 gene and t(4:14) translocations are seen in 15% of patients 49 and correlated with short progression-free survival and resistance to alkylating agents at relapse, 50 the ability of BSO to sensitize MM cells with this phenotype suggests that BSO+L-PAM may have clinical activity in the most aggressive forms of MM

Off-loading knee braces, lateral wedge insoles, canes, and shock-absorbing footwear can all provide symptomatic relief by modifying joint loading patterns

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For dietary intervention studies, mice were subjected to a high-fat diet (60/Fat, TD.06414, Envigo) for indicated period of time