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Olsen and Poulsen 1980 Olsen, P

Novo Nordisk, the manufacturer of Wegovy, offers a 7.2 mg dose to patients who do not benefit enough from the previous maximum dose of 2.4 mg

This step typically employs preparative reverse-phase high-performance liquid chromatography (RP-HPLC) under acidic conditions, such as using 0.1% trifluoroacetic acid (TFA) in a water/acetonitrile mix