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In animal studies, administering Akkermansia reversed several features of diet-induced metabolic dysfunction, including fat mass gain and gut barrier disruption

NSAIDs), when used frequently Severe or chronic stress Infections or inflammatory bowel disease Intense, prolonged exercise in the heat Severe illness, burns, or major surgery When these factors manifest, tight junctions in the wall can become loose, a phenomenon known scientifically as increased intestinal permeability, a.k.a., leaky gut. While leaky gut syndrome as a catch-all diagnosis is still debated, the underlying biology, i.e., barrier damage and increased permeability, is very real and measurable