PF-5274857 tor (benzenesulfonate) InChi: InChI=1S/C8H8N2O3S/c9-14(11

InChi: InChI=1S/C8H8N2O3S/c9-14(11

31)32/h3-12

Chemical Name: 3-(2-(2-((2-(2

RG7388 binds to MDM2 blocking the interaction between the MDM2 protein and the transcriptional activation domain of the tumor suppressor protein p53

PF 6447475

PF-5274857 tor (benzenesulfonate) InChi: InChI=1S/C8H8N2O3S/c9-14(11PF 5274857 is a potent, orally active and selective hedgehog (Hh) signaling pathway inhibitor with an IC50 of 5. 8 nM and a Ki of 4. 6 nM. PF 5274857 was found to effectively penetrate the blood brain barrier and inhibit Smo activity in the brain of primary medulloblastoma mice, resulting in improved animal survival rates. PF 5274857 was orally available and metabolically stable in vivo. PF 5274857 is a potentially attractive clinical candidate for