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ARRY-520 (R) 30002 PubMed PMID: 24403055

ARRY-520 (R) 30002 PubMed PMID: 24403055

Name: ARRY-520 (R) 30002 PubMed PMID: 24403055
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SKU: 95554640249
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SKU: 95554640249

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ARRY-520 (R) 30002 PubMed PMID: 24403055ARRY 520 R enantiomer is the R form of ARRY 520, which is a synthetic, small molecule kinesin spindle protein (KSP) inhibitor. ARRY 520 had low nanomolar antiproliferative activity in tumor cell lines and specifically inhibits KSP (kinesin 5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, and consequently cell death in tumor cells that are actively dividing. Product

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Description

PubMed PMID: 24403055

306(5705):2257-60

Formulation: 5

4% Tween-80

Smiles: CC(C)OC1C=CC(=CC=1)C1=CN2N=CC(=C2N=C1)C1=CC=NC2=CC=CC=C21

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