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Food Science & Nutrition, 8 (12), 6691

The affinity of SARS-CoV-2 for ACE2 receptors makes the virus prone to cause vascular infection that could explain atherosclerosis progression and arterial and venous thrombosis (Vinciguerra et al., 2020

Its enhanced stability and high receptor affinity produce consistent activation of downstream pathwaysmTOR, MAPK, and PI3K/Aktcritical for studies of cell proliferation , protein synthesis , and glucose metabolism

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Another study highlights that competitive uptake of extracellular glutamine by clear cell renal carcinoma activates hypoxia-inducible factor 1 (HIF-1) in tumor-infiltrating macrophages, inducing IL-23 secretion (81)