Chidamide 0066 Ethionamide is a second-line antitubercular

Ethionamide is a second-line antitubercular agent that inhibits mycolic acid synthesis

PubMed PMID: 22806357

5-8H2/t13-

InChiKey: QSZFKRINVAUJGQ-UHFFFAOYSA-N

Inhibition was observed at heteromeric ASIC channels

Chidamide 0066 Ethionamide is a second-line antitubercularTucidinostat (also known as HBI 8000, Chidamide, and CS 055) is a benzamide type inhibitor of histone deacetylase (HDAC) isoenzymes 1, 2, 3 and 10, with potential antineoplastic activity. Tucidinostat selectively binds to and inhibits HDAC leading to an increase of acetylation levels of histone protein H3. This agent also inhibits the expression of signaling kinases in the PI3K Akt and MAPK Ras signaling pathways and may result in cell cycle arrest