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R428 - CAS# 1037624-75-1 Catalog No.:M10306-2 Formula: C49H60N4O14

R428 - CAS# 1037624-75-1 Catalog No.:M10306-2 Formula: C49H60N4O14

Name: R428 - CAS# 1037624-75-1 Catalog No.:M10306-2 Formula: C49H60N4O14
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R428 - CAS# 1037624-75-1 Catalog No.:M10306-2 Formula: C49H60N4O14Bemcentinib, also known as BGB 324 or R428, is a selective small molecule inhibitor of Axl kinase, which showed activity to blocks tumor spread and prolongs survival in models of metastatic breast cancer. The receptor tyrosine kinase Axl may play an important role in cancer progression, invasion, metastasis, drug resistance, and patient mortality. R428 inhibits Axl with low nanomolar activity and blocked Axl dependent events, including Akt

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Formula: C49H60N4O14

SW044248 (10 μM) rapidly activates the integrated stress response through kinases GCN2 and PKR

63(6):2097-113

71(1):197-205

is a potent Nav1

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