LY3009120 BP Degrader-3 Prestwick_908

Prestwick_908

Bimatoprost elicits an immediate

an enzyme which catabolizes the abundant neuropeptide N-acetyl-aspartyl-glutamate (NAAG) to N-acetylaspartate (NAA) and glutamate

Tomochika K

33(5):332-353

LY3009120 BP Degrader-3 Prestwick_908LY3009120, also known as DP 4978, is potent and selective pan RAF inhibitor with potential anticancer activity. LY3009120 showed activities against BRaf or Ras mutant tumor cells . LY3009120 binds to ARaf, BRaf and CRaf isoforms with similar affinity in cells with activating mutations of BRaf or KRas. LY3009120 induces minimal paradoxical pathway activation in NRas or KRas mutant cells. LY3009120 inhibits MEK phosphorylation and cell proliferation in