GSK256066 (2,2,2-trifluoroacetic acid) rbidopa 3)10-11-21-15(13-17(23)24)18(25)22-16(19(26)27-4)12-14-8-6-5-7-9-14/h5-9

3)10-11-21-15(13-17(23)24)18(25)22-16(19(26)27-4)12-14-8-6-5-7-9-14/h5-9

with Ki of 0

A pharmacokinetic study in rats after oral administration of a single dose of Rhizoma Corydalis Decumbentis extract

CAS Number: 951131-15-0

The TAM tyrosine kinase receptors Tyro3

GSK256066 (2,2,2-trifluoroacetic acid) rbidopa 3)10-11-21-15(13-17(23)24)18(25)22-16(19(26)27-4)12-14-8-6-5-7-9-14/h5-9GSK256066 is a potent and selective PDE4 inhibitor that can be given by inhalation, minimising the potential for side effects. GSK256066 demonstrated a protective effect on the EAR and LAR. GSK256066 is a slow and tight binding inhibitor of PDE4B (apparent IC(50) 3. 2 pM; steady state IC(50) <0. 5 pM), which is more potent than any previously documented compound, for example, roflumilast (IC(50) 390 pM), tofimilast (IC(50) 1. 6 nM), and cilomilast