YM 254890 60308 3-[(2-methylphenyl)methylsulfanyl]-6-pyridin-2-ylpyridazine

3-[(2-methylphenyl)methylsulfanyl]-6-pyridin-2-ylpyridazine

and Tau pathology by stimulating autophagy in aged triple transgenic mice

Afuresertib significantly increases caspase-3 and caspase-7 activities and apoptotic cell number among ACC-MESO-4 and MSTO-211H cells

48(1):110-4

Solubility: DMSO: 55 mg/mL(199

YM 254890 60308 3-[(2-methylphenyl)methylsulfanyl]-6-pyridin-2-ylpyridazineG protein inhibitor. Potently inhibits Gq 11 heterotrimeric G protein signaling. Inhibits ATP UTP induced Ca2+ increase in HCAE cells expressing P2Y2 receptor (IC50 = 50 nM); carbachol induced production of IP1 in CHO cells expressing M1 receptor (IC50 = 95 nM); and ADP induced Ca2+ increase in platelets, in vitro (IC50 = 2 M). Also inhibits Gs induced cAMP elevation and G protein coupled MAPK ERK signaling. Product information CAS Number: 568580 02 9