AZ 628 643 2017 Dec 14

2017 Dec 14

Safinamide is a reversible and selective monoamine oxidase B inhibitor

0001-100 μM

Hosokawa Y

Smiles: O=C(OCC1C=C(Cl)C=C(Cl)C=1)N1CCN(CCC(=O)C2=CC3OC(=O)NC=3C=C2)CC1

AZ 628 643 2017 Dec 14AZ 628 is a selective, orally available Raf inhibitor with excellent pharmacokinetic properties and robust tumor growth inhibition in xenograft studies ( (IC50 values are 29, 34 and 105 nM for c Raf1, B RafV600E and wild type B Raf, respectively). AZ 628 inhibits growth, and induces cell cycle arrest and apoptosis in colon and melanoma cell lines with the B RafV600E mutation. Product information CAS Number: 878739 06 1 Molecular Weight: 451. 52