MCU i4 0073 17S)-33-((2-(diethylamino)ethyl)sulfonyl)-17-hydroxy-6-isopropyl-7

17S)-33-((2-(diethylamino)ethyl)sulfonyl)-17-hydroxy-6-isopropyl-7

which promotes differentiation of hESCs/iPSCs to cardiomyocytes when used at the second stage of differenitation

Sequential use of CHIR99021 (in the first stage to trigger mesoderm induction of hESCs/iPSCs) followed by KY02111 (or XAV939

Burslem GM

o) exhibits good oral bioavailability (77%) and the maximum exposure level in plasma (Cmax) is 24 μM

MCU i4 0073 17S)-33-((2-(diethylamino)ethyl)sulfonyl)-17-hydroxy-6-isopropyl-7MCU i4 is a negative modulator of mitochondrial calcium (Ca2+) uniporter (MCU) complex, which binds to MICU1, a regulatory protein within MCU complex. MCU i4 reduces mitochondrial Ca2+ uptake in multiple cell lines including MEFs, MDA MB,231 and HEK293T cells, and demonstrates a negative effect on mitochondrial membrane potential. In ex vivo muscle fibres, MCU i4 reduces mitochondrial Ca2+ uptake and impairs muscle cell growth. Product information CAS