GS-9620 - CAS# 1228585-88-3 iphosphate WZ3146 significantly suppresses the growth

WZ3146 significantly suppresses the growth of EGFR mutation containing cell lines with IC50 of 3 nM in EGFR Del E746_A750 containing HCC827 cells

InChi: InChI=1S/C24H32O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23

It also inhibits PLK2 and PLK3 with IC50 of 3

coli (MG1655 strain) is approximately 125 ng/mL

including iGluSnFR (a glutamate sensor)

GS-9620 - CAS# 1228585-88-3 iphosphate WZ3146 significantly suppresses the growthVesatolimod, also known as GS 9620, is a potent and oral agonist of Toll like receptor 7 developed for finite treatment of chronic hepatitis B viral (HBV) infection, with the goal of inducing a liver targeted antiviral effect without inducing the adverse effects associated with current systemic interferon (IFN ) therapies. GS 9620 demonstrate interferon stimulated gene induction without detectable serum interferon at low oral doses. GS 9620 can induce