BML-277 ubasumstat (TAK-981) InChi: InChI=1S/C35H60N2O4

InChi: InChI=1S/C35H60N2O4

Smiles: O=C(C1C=CC(=CC=1)NS(=O)(=O)C1=CC=CC2=CC=CN=C21)N1CCN(CC2CC2)CC1

Consistent with these activated receptors being important in driving leukemogenesis Ponatinib also potently inhibits the viability of all 4 cell lines with IC50 values of 0

6)25(31)16(3)24(14)30/h10

17-heptaene

BML-277 ubasumstat (TAK-981) InChi: InChI=1S/C35H60N2O4BML 277, also known as Chk2 Inhibitor II, is a Chk2 (checkpoint kinase 2) inhibitor. BML 277 protects T cells from apoptosis by controlling the response of p53 to radiation induced DNA breaks. ML 277 has IC50 = 15 nM; Ki = 37 nM. ML 277 shows 1000 fold greater selectivity for the Chk2 serine threonine kinase than for the Cdk1 B and CK1 kinases (for which IC50 = 12 M and 17 M, respectively). Product information CAS Number: 516480 79 8 Molecular Weight: