Patched Polyclonal Antibody, 50ul DNA Oligo Synthesis The gene encodes a lysosomal

The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway

AmCyan has been adapted from the corresponding full length cDNA for higher solubility

The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines

The protein encoded by this gene was identified by its interaction with interleukin 1 receptor-like 1 (IL1RL1) and may play a role in innate immunity

Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities

Patched Polyclonal Antibody, 50ul DNA Oligo Synthesis The gene encodes a lysosomalPTCH1 (patched 1) encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of PTCH1 have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas,