LY294002 - PI3K/BET Dual Inhibitor. CAS# 154447-36-6 6057 MERcK-5 reduces IFN-γ and IL-13

MERcK-5 reduces IFN-γ and IL-13

it displayed potent antileukemic activity in bone marrow blasts from AML patients regardless of FLT3 mutation status

It was also used in an assay where primary bovine articular chondrocytes and cartilage explants were grown in the presence of TNF-a and oncostatin M to mimic cytokine-induced damage during OA pathogenesis

A very useful small molecule collection to improve CRISPR editing efficacy

I-BRD9 was used at 10 µM final concentration in vitro and in cellular assays

LY294002 - PI3K/BET Dual Inhibitor. CAS# 154447-36-6 6057 MERcK-5 reduces IFN-γ and IL-13LY294002, CAS No. 154447 36 6, is a potent and selective small molecule PI3K inhibitor, inhibits PI3K with IC50 of 0. 5 M, 0. 57 M and 0. 97 M, respectively. It is the most widely used PI3K inhibitor to study the role of phosphoinositide 3 kinases in the signal transduction pathways involved in cell migration, proliferation, survival, and metabolism. LY294002 inactivates Akt PKB, consequently inhibiting cell proliferation and inducing apoptosis. It is