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Second, due to the open-label design, both the investigators and participants were aware of the treatment allocation, which could systematically influence the evaluation of therapeutic efficacy

Adn A, Casaroli-Marano RP, Gris O, Navarro R, Bitrian E, Pelegrin L, et al

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For the second generation we repeated the process described for the first generation, and from the 50 best sequences for each group, we selected five diverse sequences as parents for the third generation