GSK2578215A - CAS# 1285515-21-0 ptan Molecular Weight: 529

Molecular Weight: 529

1H-Imidazol-2-amine

Pyridone 6 suppresses osteoclast formation and bone resorption through down-regulation of receptor activator of nuclear factor-kappaB (NF-kappaB) ligand (RANKL)-induced c-Fos and nuclear factor of activated T cells (NFAT) c1 expression

Formula: C23H26ClF4N3O3S

2015 Mar 17

GSK2578215A - CAS# 1285515-21-0 ptan Molecular Weight: 529GSK2578215A is a potent and highly selective LRRK2 kinase inhibitor. GSK2578215A induces protective autophagy in SH SY5Y cells: involvement of Drp 1 mediated mitochondrial fission and mitochondrial derived ROS signaling. Mutations in the leucine rich repeat kinase 2 (LRRK2) gene have been associated with Parkinson's disease, and its inhibition opens potential new therapeutic options. GSK2578215A induces mitochondrial fragmentation of an early step