ME0328 - PARP-3 Inhibitor. CAS# 1445251-22-8 302 InChi: InChI=1S/C20H24ClN3O4S

InChi: InChI=1S/C20H24ClN3O4S

Discovery of epigenetic regulator I-BET762: lead optimization to afford a clinical candidate inhibitor of the BET bromodomains

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis

S3I-201 induced general

3 nM and LRRK2-[G2019S] ~3

ME0328 - PARP-3 Inhibitor. CAS# 1445251-22-8 302 InChi: InChI=1S/C20H24ClN3O4SME0328, CAS No. 1445251 22 8, is a potent, selective and cell permeable PARP 3 inhibitor with IC50 of 0. 89 M. It has good selectivity against PARP 1, PARP 2 and other ARDT enzymes. Enhances CRISPR Cas9 mediated HER2 mutation frequency, resulting in increased reduction in proliferation of HER2 positive breast cancer cells. Product information CAS Number: 1445251 22 8 Molecular Weight: 321. 37 Formula: C19H19N3O2 Chemical Name: (S) 3 (4 oxo 3,4