RU-SKI 43 - Hhat Inhibitor. CAS# 1043797-53-0 60077 7a-tetrahydrothieno[3
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RU-SKI 43 - Hhat Inhibitor. CAS# 1043797-53-0 60077 7a-tetrahydrothieno[3RU SKI, CAS No. 1043797 53 0, 43 is the first potent and specific small molecule inhibitor of Hedgehog acyltransferase (Hhat), and directly inhibits palmitoylation of the Shh ligand. It was discovered by a high throughput screen using a peptide based assay to monitor Hhat mediated Shh palmitoylation (IC50 ~0. 85 M) . In vitro using purified Hhat and ShhN to analyze the kinetics of compounds inhibition of ShhN palmitoylation, RU SKI 43 behaved as an
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