JNJ-40411813 mifugin InChi: InChI=1S/C24H23F3N4O2/c25-24(26

InChi: InChI=1S/C24H23F3N4O2/c25-24(26

Su-11274 exhibits greater than 50-fold selectivity for Met versus Flk and more than 500 times selectivity versus other tyrosine kinases such as FGFR-1

Biochim Biophys Acta

2-dimethyl-2H-1-benzopyran-8-yl)-3-phenyl-2-propen-1-one

also known as S-4661 and Finibax

JNJ-40411813 mifugin InChi: InChI=1S/C24H23F3N4O2/c25-24(26JNJ 40411813, also known as ADX71149, is a positive allosteric modulator of the mGlu2 receptor. JNJ 40411813 acts as a PAM at the cloned mGlu2 receptor: EC50 = 147 42 nmol L in a [(35)S]GTPS binding assay with human metabotropic glutamate type 2 (hmGlu2) CHO cells and EC50 = 64 29 nmol L in a Ca(2+) mobilization assay with hmGlu2 G 16 cotransfected HEK293 cells. JNJ 40411813 displaced [(3)H]JNJ 40068782 and [(3)H]JNJ 46281222 (mGlu2 receptor PAMs),