SD70 - Histone Demethylase JMJD2 Inhibitor. CAS# 332173-89-4 6057 Chemical Name: Compound Library of

Chemical Name: Compound Library of Histone Demethylase

providing a strong rationale for their combined use in the clinic

Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad

[Epub ahead of print] PubMed PMID: 24365180

It is the most widely used PI3K inhibitor to study the role of phosphoinositide 3-kinases in the signal transduction pathways involved in cell migration

SD70 - Histone Demethylase JMJD2 Inhibitor. CAS# 332173-89-4 6057 Chemical Name: Compound Library ofSD70, CAS No. 332173 89 4, is a potent, selective and cell permeable inhibitor of histone demethylase JMJD2 (KDM4C), identified by phenotypic screening for inhibitors of ligand and genotoxic stress induced translocations in prostate cancer cells. Through Chem seq approach, SD70 was found to inhibit the androgen dependent AR program and prostate cancer cell growth, acting, at least in part, by functionally inhibiting the Jumonji domain containing