BI-2536 - PLK1 and BRD4 Dual Inhibitor. CAS# 755038-02-9 431 d]azepin-7-yl]-2

d]azepin-7-yl]-2

J Clin Invest

InChi: InChI=1S/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22

DNA-dependent protein kinase catalytic subunit (DNA-PKcs)-SIN1 association mediates ultraviolet B (UVB)-induced Akt Ser-473 phosphorylation and skin cell survival

2 μm and 318 nm

BI-2536 - PLK1 and BRD4 Dual Inhibitor. CAS# 755038-02-9 431 d]azepin-7-yl]-2BI 2536, CAS No. 755038 02 9, is a potent inhibitor of PLK1 (Polo like kinase 1, IC50 ~0. 83 nM) and BRD4 (IC50 ~37 nM). It also inhibits PLK2 and PLK3 with IC50 of 3. 5 nM and 9. 0 nM, respectively. BI 2536 treatment ranging from 10 nM to 100 nM leads to the blocking of the recruitment of tubulin and phosphorylation of Apc6 at mitotic centrosomes, inhibition of cohesin release from chromosome arms, induction of monopolar spindles, and other Plk1