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( R )-2-Hydroxyglutarate inhibits KDM5 histone lysine demethylases to drive transformation in IDH -mutant cancers

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Metformin remains one of the cornerstone treatments for insulin resistance, even in other endocrinopathies such as polycystic ovary syndrome, where its pleiotropic effects and its role in the treatment of this syndrome are well known [19,20,21]