TMP269 - Class IIa HDAC Inhibitor. CAS# 1314890-29-3 size:10mg solid is a widely used

is a widely used

1956356-56-1

InChiKey: VXNYQUQHOUERTR-UHFFFAOYSA-N

4-Dichlorobenzoyl)-5-bromothiophene-2-sulfonamide

KB-R7943 inhibits both IhERG and native IKr rapidly on membrane depolarization with IC50 values of ~89 and ~120 nM

TMP269 - Class IIa HDAC Inhibitor. CAS# 1314890-29-3 size:10mg solid is a widely usedTMP269, CAS No. 1314890 29 3, is a highly potent, selective and cell permeable class IIa HDAC inhibitor with IC50 of 126 nM, 80 nM, 36 nM and 19 nM for HDAC4, HDAC5, HDAC7 and HDAC9 respectively. It has very weak or no activity targeting the other HDACs (2 40 M). TMP269 has an unprecedented metal binding group, trifluoromethyloxadiazole (TFMO), which circumvents the selectivity and pharmacologic liabilities of hydroxamates. Crystallography revealed a