AZ5104 - CAS# 1421373-98-9 308 The dual mTORC1 and mTORC2

The dual mTORC1 and mTORC2 inhibitor AZD8055 inhibits head and neck squamous cell carcinoma cell growth in vivo and in vitro

EC50 = 280 nmol/L)

InChiKey: TXZPMHLMPKIUGK-UHFFFAOYSA-N

5-diyl)dibenzimidamide dihydrochloride

0 µM final concentration in vitro and in cellular assays

AZ5104 - CAS# 1421373-98-9 308 The dual mTORC1 and mTORC2AZ5104, CAS No. 1421373 98 9, is a demethylated metabolite of AZD 9291. AZ 5104 was identified to exhibit 5 fold potency compared to AZD 9291, which is currently in clinical trial. AZ5104 is a potent EGFR inhibitor with IC50 of <1 nM, 6 nM, 1 nM, and 25 nM for EGFR (L858R T790M), EGFR (L858R), EGFR (L861Q), and EGFR (wildtype), respectively. Product information CAS Number: 1421373 98 9 Molecular Weight: 485. 58 Formula: C27H31N7O2 Synonym: AZ5104 AZ