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Somwar et al

They should also seek to identify patient subgroups that may benefit the most, such as those with low baseline carnitine levels or undertaking certain procedures like PCI/CABG, evaluating safety and interactions with guideline-directed therapies

Some studies suggest benefits, while others do not find significant improvements or even suggest potential harm

In TRIUMPH-4, 18.2% of participants on retatrutide 12 mg discontinued due to adverse events, compared to 12.2% on the 9 mg dose and just 4.0% on placebo