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Situations where a conversation with a clinician is especially important include: History of heart disease, stroke, high blood pressure or peripheral arterial disease Chronic kidney disease or significant liver disease Diabetes or major endocrine issues Use of blood pressure medications, nitrates, anticoagulants or other complex medication regimens Pregnancy, breastfeeding or trying to conceive The use in individuals under the age of 18 High protein diets may not be appropriate for everyone, and peptide therapies or IV infusions require valid prescriptions from providers

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With that regulatory brake reduced, IGF-1 LR3 interacts with IGF-1 receptors more directly and for a longer duration, which is why research protocols report a half-life of roughly 2030 hours, compared to native IGF-1s 1215 hours

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