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GSK591 (EPZ015866) - PRMT5 Inhibitor. CAS# 1616391-87-7 Catalog No.:M60321-10S InChi: InChI=1S/C18H16O4/c1-11(2)22-14-7-8-15-17(9-14)21-10-16(18(15)20)12-3-5-13(19)6-4-12/h3-11

GSK591 (EPZ015866) - PRMT5 Inhibitor. CAS# 1616391-87-7 Catalog No.:M60321-10S InChi: InChI=1S/C18H16O4/c1-11(2)22-14-7-8-15-17(9-14)21-10-16(18(15)20)12-3-5-13(19)6-4-12/h3-11

Name: GSK591 (EPZ015866) - PRMT5 Inhibitor. CAS# 1616391-87-7 Catalog No.:M60321-10S InChi: InChI=1S/C18H16O4/c1-11(2)22-14-7-8-15-17(9-14)21-10-16(18(15)20)12-3-5-13(19)6-4-12/h3-11
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GSK591 (EPZ015866) - PRMT5 Inhibitor. CAS# 1616391-87-7 Catalog No.:M60321-10S InChi: InChI=1S/C18H16O4/c1-11(2)22-14-7-8-15-17(9-14)21-10-16(18(15)20)12-3-5-13(19)6-4-12/h3-11GSK591, also known as EPZ015866 and GSK3203591, CAS No. 1616391 87 7, is a chemical probe for PRMT5. In an in vitro biochemical assay, GSK591 potently inhibits the PRMT5 MEP50 complex from methylating (histone) H4 with IC50 = 11 nM. In Z 138 cells, GSK591 inhibits the symmetric arginine methylation of SmD3 with EC50 = 56 nM. Further, GSK591 is selective for PRMT5 (up to 50 micromolar) relative to a panel of methyltransferases. Product information CAS

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Description

InChi: InChI=1S/C18H16O4/c1-11(2)22-14-7-8-15-17(9-14)21-10-16(18(15)20)12-3-5-13(19)6-4-12/h3-11

1-4H3/t15-

Zarybnicka L

CAS Number: 955365-80-7

InChi: InChI=1S/C35H49F2N7O4/c1-5-34(6-2

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