APD668 S-1286937 Twynholm M

Twynholm M

FGFR inhibitor ARQ 087 binds to and potently inhibits the activity of FGFR subtypes 1

InChiKey: AOZPVMOOEJAZGK-UHFFFAOYSA-N

Weinstein SF

Chemical Name: 2-chloro-N-{[2'-(cyanosulfamoyl)-[1

APD668 S-1286937 Twynholm MAPD668, also known as JNJ 28630368, is a potent GPR119 agonist with EC50 of 2. 7 nM and 33 nM for hGPR119 and ratGPR119 respectively. Receptor GPR119 is a target that has been of significant recent interest in the field of metabolism. ADP668 showed activity to reduce blood glucose and glycated hemoglobin (HbA1c) levels in Zucker Diabetic Fatty (ZDF) rats over several weeks of dosing. ADP668 is currently under clinical trial for diabetes. Product