SB-222200 Size:Solid 10 mg Formula: C16H15N3O

Formula: C16H15N3O

3ClH/c1-26(15-7-3-2-4-8-16-26)29-18-13-22(14-19-29)30-24-12-6-5-11-23(24)28-25(30)21-10-9-17-27-20-21

Chemical Name: N-(3-((2-((4-(4-acetylpiperazin-1-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide

studies performed in vivo show that orally administered chrysin does not have clinical activity as an aromatase inhibitor

Administration of AZD-2281(50 mg/kg

SB-222200 Size:Solid 10 mg Formula: C16H15N3OSB 222200 is a central nervous system penetrant, potent and selective NK 3 receptor antagonist. SB 222200 inhibited (125)I [MePhe(7)]neurokinin B (NKB) binding to Chinese hamster ovary (CHO) cell membranes stably expressing the hNK 3 receptor (CHO hNK 3R) with a K(i) = 4. 4 nM and antagonized NKB induced Ca(2+) mobilization in HEK 293 cells stably expressing the hNK 3 receptor (HEK 293 hNK 3R) with an IC(50) = 18. 4 nM. SB 222200 was selective for hNK