MERcK-5 - CAS# 457081-03-7 size:2mg solid In August 2012
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MERcK-5 - CAS# 457081-03-7 size:2mg solid In August 2012Pyridone 6, also known CMP 6 or JAK Inhibitor I, CAS No. 457081 03 7, is a pan Janus activated kinase inhibitor, Pyridone 6 interferes with JAK kinase activity by interacting within the ATP binding cleft. It inhibits JAK1, 2, and 3 with IC50 values of 15, 1, and 5 nM, respectively. Pyridone 6 suppresses osteoclast formation and bone resorption through down regulation of receptor activator of nuclear factor kappaB (NF kappaB) ligand (RANKL) induced c
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