HI-TOPK-032 - TOPK inhibitor. CAS# 487020-03-1 stat Behrendt HJ

Behrendt HJ

providing a strong rationale for their combined use in the clinic

is a potent inhibitor of MEK5 (IC50 = 4

is an inhibitor of the Lysine Acetyltransferase

induces growth inhibition and apoptosis in human gastric cancer cells

HI-TOPK-032 - TOPK inhibitor. CAS# 487020-03-1 stat Behrendt HJHI TOPK 032 is a potent and selective TOPK inhibitor. HI TOPK 032 also reduces ERK RSK phosphorylation, regulates of the abundance of p53, cleaved caspase 7, and cleaved PARP, and induces apoptosis in cancer cells. In vitro, HI TOPK 032 strongly suppressed TOPK kinase activity but had little effect on extracellular signalregulated kinase 1 (ERK1), c junNH2kinase 1, or p38 kinase activities. HI TOPK 032 also inhibited anchorage dependent and