PF-670462 2HCl - CAS# 950912-80-8 0158 WO 2012118978 A1 20120907

WO 2012118978 A1 20120907

and 50 mg/kg for 18 months (groups O

TAS-301 (1-10 μM) concentration-dependently inhibits PKC activation and Ca2+ influx

is an ATM inhibitor

hydrochloride is an oral bioavailabile TGF-beta signaling agonist

PF-670462 2HCl - CAS# 950912-80-8 0158 WO 2012118978 A1 20120907PF 670462 2HCl, CAS No. 950912 80 8, is a potent inhibitor of the CK1 isoforms CK1 and CK1 (IC50 = 7. 7 and 14 nM, respectively). Inhibition of CKIepsilon yields a perturbation of oscillator function that forestalls light as a zeitgeber, and they demonstrate that pharmacological tools such as PF 670462 may yield valuable insight into clock function. Casein kinase Iepsilon (CKIepsilon) is an essential component of the biological clock, phosphorylating