Cobicistat - CAS# 1004316-88-4 iin a focal adhesion kinase (FAK)

a focal adhesion kinase (FAK) inhibitor in Japanese patients with advanced solid tumors

also know as AC220 and AC010220

28+/m0/s1/i4D2

the specific activity of the enzyme for 1 μM Fluorescein diacetate is determined to be 79±15 nmol/min/mg protein

The agent may enhance expression of the TGFβ-1 gene in a fashion analogous to that demonstrated for CsA

Cobicistat - CAS# 1004316-88-4 iin a focal adhesion kinase (FAK)Cobicistat, also known as GS9350, is an approved drug for use in the treatment of infection with the human immunodeficiency virus (HIV). Like ritonavir (Norvir), cobicistat is of interest not for its anti HIV properties, but rather its ability to inhibit liver enzymes that metabolize other medications used to treat HIV, notably elvitegravir, an HIV integrase inhibitor currently under investigation itself. By combining cobicistat with elvitegravir,