TAK-733 Size:2mg solid Y-39983 HCl

Y-39983 HCl

eCollection 2013

significantly inhibits MM tumor growth

BMP type I receptor inhibition reduces heterotopic ossification

Ferroptosis is dependent upon intracellular iron

TAK-733 Size:2mg solid Y-39983 HClTAK 733 is an orally bioavailable small molecule inhibitor of MEK1 and MEK2 (MEK1 2) with potential antineoplastic activity. MEK inhibitor TAK 733 selectively binds to and inhibits the activity of MEK1 2, preventing the activation of MEK1 2 dependent effector proteins and transcription factors, which may result in the inhibition of growth factor mediated cell signaling and tumor cell proliferation. MEK1 2 (MAP2K1 K2) are dual specificity threonine