CX-6258 - CAS# 1202916-90-2 size:10mg solid PubMed Central PMCID: PMC4866285

PubMed Central PMCID: PMC4866285

G9a (EHMT2) and GLP (EHMT1) catalyze the mono and dimethylation of lysine 9 of histone 3 (H3K9) and other non-histone substrates such as p53 and WIZ

24-48 hours) inhibits LnCAP and MCF7 cells viability in a dose-dependent manner

Nakamura Y

InChi: InChI=1S/C22H20ClF3N4O3S/c1-15-8-9-27-30(15)17-4-2-16(3-5-17)21(31)28-10-12-29(13-11-28)34(32

CX-6258 - CAS# 1202916-90-2 size:10mg solid PubMed Central PMCID: PMC4866285CX 6258, CAS No. 1202916 90 2, is a pan Pim kinases inhibitor with excellent biochemical potency and kinase selectivity. CX 6258 exhibited in vitro synergy with chemotherapeutics and robust in vivo efficacy in two Pim kinases driven tumor models. Inhibition of Pim kinases is expected to have a beneficial effect as cancer therapy. Product information CAS Number: 1202916 90 2 Molecular Weight: 461. 94 Formula: C26H24ClN3O3 Synonym: CX6258 CX 6258 CX