AUY-922 - CAS# 747412-49-3 Catalog No.:M6487-10 BI-2536 treatment ranging from 10

BI-2536 treatment ranging from 10 nM to 100 nM leads to the blocking of the recruitment of γ-tubulin and phosphorylation of Apc6 at mitotic centrosomes

CH223191 (0

is a potent EGFR inhibitor with Ki and IC50 of 6 and 25 pM

a BET bromodomain inhibitor now in clinical development

PubMed Central PMCID: PMC3955649

AUY-922 - CAS# 747412-49-3 Catalog No.:M6487-10 BI-2536 treatment ranging from 10AUY 922, also known as Luminespib, NVP AUY922, VER52296, CAS No. 747412 49 3, is a derivative of 4, 5 diarylisoxazole and a third generation heat shock protein 90 (Hsp90) inhibitor with potential antineoplastic activity. Hsp90 inhibitor AUY 922 has been shown to bind with high affinity to and inhibit Hsp90, resulting in the proteasomal degradation of oncogenic client proteins; the inhibition of cell proliferation; and the elevation of heat shock