ISRIB (trans-isomer) - Inhibitor of “Integrated Stress Response” (ISR). CAS# 1597403-47-8 LSB HLY78 as a specific Wnt

HLY78 as a specific Wnt synergistic activator presents another opportunity for potential clinical applications relevant to the Wnt pathway

DMOG was used at 100 µM final concentration in vitro and in cellular assays

2013 Oct 22

Molecular Weight: 374

in non-small cell lung cancer cell lines

ISRIB (trans-isomer) - Inhibitor of “Integrated Stress Response” (ISR). CAS# 1597403-47-8 LSB HLY78 as a specific WntISRIB (trans isomer), CAS No. 1597403 47 8, is a potent inhibitor of PERK with an IC50 of 5 nM. ISRIB potently reverses the effects of eIF2 phosphorylation (IC50=5 nM). In cells, distinct stress conditions activate different downstream kinases, including PERK, that converge on phosphorylating the subunit of initiation factor 2 (eIF2 ). This collection of signaling pathways is termed the integrated stress response (ISR). Trans ISRIB is a potent and