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Rigosertib - CAS# 592542-59-1 Catalog No.:M10594-10 Formula: C28H28F2N6O3

Rigosertib - CAS# 592542-59-1 Catalog No.:M10594-10 Formula: C28H28F2N6O3

Name: Rigosertib - CAS# 592542-59-1 Catalog No.:M10594-10 Formula: C28H28F2N6O3
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SKU: 46809848920

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Rigosertib - CAS# 592542-59-1 Catalog No.:M10594-10 Formula: C28H28F2N6O3Rigosertib (ON 01910 sodium salt) is a synthetic benzyl styryl sulfone analogue with potential antineoplastic activity. Polo like kinase 1 inhibitor ON 01910. Na inhibits polo like kinase1 (Plk1), inducing selective G2 M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. This agent may exhibit synergistic antitumor activity in combination with other

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Description

Formula: C28H28F2N6O3

Smiles: CC(C)OC(=O)[C@H](C)N[P@@](=O)(OC[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@](C)(F)[C@@H]1O)OC1=CC=CC=C1

CNCC/C=C/C1=CN=CC=C1

particularly in the small bowel

Biochemistry

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