Dvl-2 Polyclonal Antibody, 100ul Monoclonal Antibody Preparation Alternatively spliced transcript variants encoding

Alternatively spliced transcript variants encoding distinct isoforms have been reported

chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors

A similar secreted protein in mouse plays a role in left-right asymmetry determination of organ systems during development

Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome

This gene encodes a member of the G-protein-coupled receptor 1 family

Dvl-2 Polyclonal Antibody, 100ul Monoclonal Antibody Preparation Alternatively spliced transcript variants encodingDVL2 encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. DVL2 encodes a 90 kD protein that undergoes posttranslational phosphorylation to form a 95 kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved